https://www.selleckchem.com/pr....oducts/ac-fltd-cmk.h
Dual-specificity mitogen-activated protein kinase phosphatase-1 (MKP-1/DUSP1/CL-10 has been documented to promote breast cancer cell survival and chemoresistance. MKP-1 is an unstable protein that is ubiquitinated and degraded via the ubiquitin-proteasome system. However, it is not clear how MKP-1 protein stability is regulated in breast cancer. In this study, we performed a genome-wide siRNA library screen of deubiquitinases (DUBs) and identified STAMBPL1 as an MKP-1 DUB in breast cancer cells. STAMBPL1 interacts with MKP-1 and s
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