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Conclusion The use of MZB appeared to suppress the pathophysiology of anti-ARS antibody-associated ILD.Introduction As the average life expectancy is increasing, the number of patients aged 100 years who have fragility fractures will increase in the future. In female patients, the incidence of open fractures increases with age. Case Presentation We present the case of a 102-year-old woman with open tibial and fibular diaphyseal fractures (Gustilo-Anderson classification type IIIb) treated with temporary external fixation, advancemen