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and compared to that of other published databases. This study presents DB4Q2, a detailed procedure to develop custom reference databases in order to carry out taxonomic analyses with QIIME2, but also with other bioinformatics platforms if desired. This work also provides ready-to-use plant ITS2 and rbcL databases for which the prediction accuracy has been assessed and compared to that of other published databases. For outcome measures to be useful in health and care decision-making, they need to have certain psychometric properties. The ICECAP-Supportive Ca

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