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oups, and ( 0.01) was significantly increased. Berberine has a substantial effect in improving metabolic parameters and modulating the gut microbiota composition in T2DM rats. Berberine has a substantial effect in improving metabolic parameters and modulating the gut microbiota composition in T2DM rats. Gallbladder cancer (GBC) is an aggressive type of biliary tract cancer that lacks effective therapeutic targets. Fork head box M1 (FoxM1) is an emerging molecular target associated with tumor progression in GBC, and accumulating ev