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Compared with the control group, the Lequesne total score, the separation degree of trabecular bone, the protein and mRNA expressions of RANKL and RANK in subchondral bone tissues were significantly increased in the model group, while the percentage of trabecular bone area, number of trabecular bone, the expression of OPG protein and mRNA were decreased ( 0.05, 0.01). The above indexes were all reversed in the treatment group relevant to those of the model group ( 0.05). The internal heat-type acupuncture needle therapy can im