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0 and 8.0 months, respectively (p=0.004). The median OS was 10.3 and 18.1 months, respectively (p=0.001). Multivariate analyses revealed that sarcopenia was an independent prognostic factor for PFS and OS (p=0.004, p=0.001, respectively). The rates of major grade 3 or 4 AEs were significantly higher in the sarcopenia group (p=0.008). Sarcopenia is an independent indicator of a poor prognosis in patients with PDAC treated with first-line GEM and nab-PTX. Sarcopenia is an independent indicator of a poor prognosis in patients with PDAC tre