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Our findings are consistent with the clinical profile and prior cross-sectional data, helping to establish reasonable expectations of functional trajectories in this population as well as identifying points in which therapeutic interventions may be best studied. Further study of outcomes in children 10 y old and 3 y is warranted, but this new information will assist planning of clinical trials in the CDM population. 10 y old and less then 3 y is warranted, but this new information will assist planning of clinical trials in the CD