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IgE production against innocuous food antigens can result in anaphylaxis, a severe life-threatening consequence of allergic reactions. The maintenance of IgE immunity is primarily facilitated by IgG memory B cells, as IgE memory B cells and IgE plasma cells are extremely scarce and short-lived, respectively. Our aim was to investigate the critical requirements for an IgE recall response in peanut allergy. We used a novel human PBMC culture platform, a mouse model of peanut allergy, and various experimental readouts to assess the IgE reca

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