https://www.selleckchem.com/pr....oducts/otub2-in-1.ht
The SAR analysis indicated the leishmanicidal activity of title compounds depended upon the type of substituents on N4 of piperazine. The in silico physicochemical properties, pharmacokinetic profile, and drug likeness predictions were also carried out for the all synthesized compounds and MTZ. The molecular docking study was also conducted to predict the binding mode and the interaction of 9d as the most and 9a as the least active compounds with pteridine reductase 1 (PTR1) enzyme. The docking results determined that 9d exhibited a
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