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Because BRCA1 and BRCA2 proteins play a role in DNA damage restoration, we postulated that taxane-related poisoning is possibly higher and medical outcome in different in customers with BRCA pathogenic variations (PV). Seven hundred nineteen women who underwent BRCA hereditary testing and were treated with taxane-containing chemotherapy for early-stage cancer of the breast between 1997 and 2018 were included in the study. Patients with BRCA variations of uncertain

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