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Adding the NHPT to a combined outcome added only few further worsening events. PASAT scores slightly increased over time, possibly due to a practice effect. Both the EDSS and T25FW, but not NHPT or PASAT, appear to be useful outcome measures in PPMS. Both the EDSS and T25FW, but not NHPT or PASAT, appear to be useful outcome measures in PPMS.Objective Few studies have investigated the efficacy of subcutaneous tocilizumab (TCZ-SC) on ultrasound-detected inflammation. This study aimed to explore the clinical efficacy of TCZ-SC treatment in