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Within our outcomes, mecamylamine (3 mg/kg) showed antidepressant-like properties, plus it tended to have anxiolytic-like impacts, though perhaps not considerable. Concomitant treatment of subthreshold amounts of mecamylamine (1 mg/kg) and l-arginine (25 mg/kg), l-NAME (1 mg/kg), or l-arginine/L-NAME had been antidepressive. In comparison, l-arginine/L-NAME alone or in related to mecamylamine revealed anxiogenic-like effectiveness. Isobolographic analysis displayed
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