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7 letters, P = 0.012 or 17.2 letter, P 0.001, respectively). Longitudinal modeling for CLS-TA treated eyes showed that central subfield thickness (CST) reached 90% of maximal improvement by week three, whereas 90% maximal response in BCVA was not reached until week nine. NIU-ME eyes receiving CLS-TA that showed a CST reduction of ≥ 50 µm at 4 weeks experienced a greater 24-week improvement in BCVA, compared to those without such an early response (14.6 vs 6.5 letters, P=0.006 for difference). Pre-treatment EZ integrity an