https://www.selleckchem.com/pr....oducts/sch772984.htm
KRAS inhibitors have shown promising efficacy in early clinical trials, but drug resistance compromises their long-term benefits. Therefore, it is critical to understand the mechanisms of drug resistance and to design appropriate combinatory treatments to improve efficacy. To understand the comprehensive mechanisms of drug resistance, we treated lung cancer cells with KRAS inhibitors for different periods and performed transcriptional profiling and signaling analysis to identify critical factors and pathways that drive drug tolerance
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