https://www.selleckchem.com/pr....oducts/momordin-ic.h
in.During drug development, potential safety issues can occur at any time. Understanding the cause of a toxicity can help with deciding on how to advance the drug development program. Chemoproteomics provides a way to help understand the cause of a toxicity where the affected tissue is accessible and can be probed with a covalently binding compound that is analogous to the offending drug. In this case, CC-292, a covalently binding Bruton's Tyrosine Kinase (BTK) inhibitor, had produced testicular toxicity in rodents. Experiments were
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