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Almost complete clearance of ET-26-HCl from plasma occurred within 4 h after administration. Only a small fraction of the parent compound and its acid form were excreted via the urine and faeces. Taken together, the results added to a better understanding of the metabolic and pharmacokinetic properties of ET-26-HCl, which may contribute to the further development of this drug. © 2020 The Authors.The present paper reports the catalytic influence of 16-s-16 (spacer (s) = 4, 5, 6) gemini surfactants on the rate constant of histidine and ninh