What Causes Trucking Accidents? Trucks make up a tiny portion of the vehicles on road, but they are a risk and can cause serious injuries or even death. Accidents involving large trucks may be caused by drivers who are distracted or fail to pay attention to their blind areas. Driver fatigue can also cause trucking accidents. They often work long hours with no breaks to meet their quotas. Driver Error Driver errors are the leading cause of trucking accidents, and it is a very serious issue. There are a myriad of factors that can contribute to