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7; P0.0005). A SI threshold value ≥0.6 showed sensitivity of 100%, specificity of 80%, positive predictive value of 54%, negative predictive value of 100%, and the area under the curve of 84%. SI seems to be a good AS definer and prognostic tool; our study suggests that an AS could be defined by a SI ≥0.6. SIEN seems to be a good AS definer and prognostic tool; our study suggests that an AS could be defined by a SIEN ≥0.6. To evaluate the existing literature comparing cardiopulmonary complications after minimally invasive esophagectomy (MIE) with open e