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00; 95% CI 1.27-12.58; P=0.02) and multivariant analysis (OR 4.41; 95% CI 1.35-14.37; P=0.014). Conclusion Our study is the first to focus on ASO levels in patients with CD and to demonstrate a significant association between ASO and new-onset of CD. Large prospective randomized controlled studies are needed to confirm the validity of this data and to further clarify the clinical significance of our findings.Background Skin aging is characterized by slacking and loss of density, especially under ultraviolet (UV) radiation exposu