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https://www.selleckchem.com/pr....oducts/Rapamycin.htm
His infection resolved and pain improved. He was discharged with outpatient rheumatology follow up. Discussion Erythromelalgia is a highly debilitating disease with episodes of burning erythematous extremities triggered by increase in skin temperature. Patients seek pain relief by excessive external cooling. Pathophysiology involves gain of function mutation in voltage gated sodium channels causing autoregulatory dysfunction of skin. Underlying disease mechanisms are ambiguous and may involve unidentified genetic components and unknow

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