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1%. Patients undergoing surgery had better median survival than those who did not (38.1 vs 21.0 months, P = .04). Age, comorbidity, tumor size, and surgical margins were significant factors in univariate analyses. On multivariable analysis, age ≥75 years (hazard ratio, 2.65; 95% CI, 1.80-3.88; P less then .001) and positive margins (hazard ratio, 1.91; 95% CI, 1.44-2.51; P less then .001) predicted worse overall survival. CONCLUSION Angiosarcoma of head and neck is a rare malignancy that affects the elderly. Surgical treatment with negati