https://www.selleckchem.com/pr....oducts/R7935788-Fost
Single genetic mutations predispose to very early onset inflammatory bowel disease (VEO-IBD). Here, we identify a de novo duplication of the 10p15.1 chromosomal region, including the IL2RA locus, in a 2-year-old girl with treatment-resistant pancolitis that was brought into remission by colectomy. Strikingly, after colectomy while the patient was in clinical remission and without medication, the peripheral blood CD4CD8 ratio was constitutively high and CD25 expression was increased on circulating effector memory, Foxp3+, a
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