https://www.selleckchem.com/products/MK-1775.html
OBJECTIVE Recent studies showed that FVIIa (factor VIIa), upon binding to endothelial cell protein C receptor, elicits endothelial barrier stabilization and anti-inflammatory effects via activation of PAR (protease-activated receptor)-1-mediated signaling. It is unknown whether FVIIa induces PAR1-dependent cytoprotective signaling through cleavage of PAR1 at the canonical site or a noncanonical site, similar to that of APC (activated protein C). Approach and Results Mouse strains carrying homozygous R41Q (canonical site) or R46Q (noncan
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