https://www.selleckchem.com/pr....oducts/shin1-rz-2994
By fine-tuning the microenvironment of the reactive cysteine residue, this strategy offers a simplified protocol for production of site-selectively coupled ADCs. Our unique approach allows the generation of therapeutic ADCs with controlled chemical composition, which facilitates the optimization of their pharmacological activity. This strategy for directional coupling could in the future simplify the construction of ADCs with double payloads ("dual warheads" introduced with orthogonal techniques. Our unique approach allows the ge
Like
Comment
Share
