https://www.selleckchem.com/pr....oducts/ripasudil-k-1
Introduction Hypoxia-inducible factor (HIF) is a master regulator of oxygen homeostasis. The increased expression of genes targeted by HIF is associated with many human diseases, including ischemic cardiovascular disease, stroke, chronic lung disease, and cancer.Areas covered This patent survey summarizes the information about patented HIF inhibitors over the last 5 years.Expert opinion HIF inhibitors have shown promise for the treatment of hypoxic pulmonary hypertension, a circadian rhythm disorder, calcific aortic valve diseas