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Our findings suggest that a depalmitoylation inhibitor, PalmB, is useful as a potentially novel adjuvant treatment for patients with GBM undergoing radiation therapy. Our data present novel mechanistic evidence relating to signaling pathways with DNA damage responses in EGFR-mutated GBM. Our data present novel mechanistic evidence relating to signaling pathways with DNA damage responses in EGFR-mutated GBM.Antibiotics accumulation in the environment has given rise to multi-drug resistant 'superbugs' and antibiotics resistence genes (ARGs)