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Objective Few studies have investigated the association of apolipoprotein B (Apo with the progression of diabetic kidney disease (DKD) and the risk of renal replacement therapy (RRT).Method In this retrospective cohort study, a group of 258 DKD patients with stage 3-5chronic kidney disease(CKD)were divided into low ApoB ( less then 1.1 g/L) and high ApoB (≥1.1 g/L) groups and followed-up for 20.51 ± 6.11 months. The association of the serum ApoB concentration with RRT was determined by Kaplan-Meier and Cox regression analysis. ApoB was