https://www.selleckchem.com/pr....oducts/blasticidin-s
We also observed that depletion of the hypoxia-inducible factor (HIF) genes, HIF1A (encoding HIF-1α) and endothelial PAS domain protein 1 (EPAS1 encoding HIF-2α) inhibited both distinct and overlapping transcriptional programs. Our results indicated a role for HIF1A in down-regulating mitochondrial metabolism, while concomitantly up-regulating glycolytic genes, whereas EPAS1 primarily up-regulated the angiogenesis transcriptional program. These results identify the concentration and time dependence of the endothelial transcrip
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