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3pmol/L for copeptin and 16.8ng/L for hs-cTnI and an increase of either biomarker was significantly associated with the primary endpoint. The combination of raised hs-cTnI and copeptin yielded a superior prognostic value to individual measurement of biomarkers and was a strong prognostic marker upon multivariable logistic regression analysis (OR 4.274 [95% CI, 1.995-9.154], P  0.001). Addition of copeptin and hs-cTnI to established risk models improved C-statistics and net reclassification indices. The combination of raised copeptin an