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Theoretical and empirical studies were examined to define distress, describe the nature and impact of the stress response, and determine how distress interacts with GRD, obesity, and advancing age. The literature was used to create a conceptual framework and model consisting of the interactions among the variables. Conclusion The Stress and Coping Framework for Type 2 Diabetes Mellitus shows how distress can contribute to the development of T2DM by interacting directly with established risk factors and in promoting insulin resistance.Aim