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Purpose The purpose of this study was to examine the differences in immunopathogenesis based on the cytokine/chemokine profiles in myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-positive and -negative groups. Methods We measured the levels of T-helper cell 17 (Th17) cell-related cytokines/chemokines in 74 serum samples, which were divided into four groups healthy control (HC) group (n = 15), idiopathic demyelinating optic neuritis (IDON) group (n = 2, aquaporin 4 (AQP4)-IgG-positive optic neuritis (ON) group (n = 18), and MOG-
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