https://www.selleckchem.com/MEK.html
Remarkably, a single rattlesnake-mimicking substitution in the conserved but presumably dormant cytosolic Ca2+-binding domain of bTRPA1 substantially enhanced thermosensitivity through cytosolic Ca2+ like rsTRPA1, indicating the capability of this single site in the determination of both cytosolic Ca2+ dependence and thermosensitivity. Collectively, these data suggest that Ca2+ is essential for the hyper-thermosensitivity of these TRPA1s, and cytosolic potentiation by permeating Ca2+ may contribute to the natural variation of infrared senses between
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