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BACKGROUND Chromoblastomycosis is a chronic, progressive fungal disease of the skin and subcutaneous tissue caused by a unique group of dematiaceous fungi. Fonsecaea monophora, a new species distinct from Fonsecaea pedrosoi strains, is the main pathogen responsible for chromoblastomycosis in south China. Macrophages can be polarized into two categories classically activated and alternatively activated. OBJECTIVES Little is known about the relationship between F. monophora and macrophage polarization. This study aimed to study the effect o