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The overall association evidence of a genetic variant with multiple traits can be evaluated by cross phenotype association analysis using summary statistics from genome wide association studies (GWAS). Further dissecting the association pathways from a variant to multiple traits is important to understand the biological causal relationships among complex traits. Here we introduce a flexible and computationally efficient Iterative Mendelian Randomization and Pleiotropy (IMRP) approach to simultaneously search for horizontal pleiotropic va