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nternational Prospective Register of Systematic Reviews; No. CRD42018093602; URL https//www.crd.york.ac.uk/prospero/. International Prospective Register of Systematic Reviews; No. CRD42018093602; URL https//www.crd.york.ac.uk/prospero/.Major depressive disorder (MDD) is a debilitating disorder that interferes with daily functioning, and that occurs at higher rates in women than in men. Structural and functional alterations in hippocampus and frontal lobe have been reported in MDD, which likely contribute to the multifaceted nature of MD
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