https://www.selleckchem.com/pr....oducts/trastuzumab-d
We demonstrated that, mechanistically, RUNX1 and CBFA2T3 can be part of the same complex allowing CBFA2T3 to strongly potentiate the activity of the transcription factor RUNX1. Finally, we characterized a CBFA2T3-mimicking peptide that inhibits the interaction between RUNX1 and CBFA2T3, abrogating the activity of this transcription complex and reducing BCP-ALL lymphoblast proliferation. Altogether, our findings reveal a novel and important activation loop between the transcription regulator CBFA2T3 and the transcription f
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