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Intestinal permeability and histopathologic score were significantly reduced (P less then 0.05). The expression level of GC-C, Gn, Ugn, claudin-1 and ZO-1 was significantly increased (P less then 0.05). The level of IL-8 and TNF-α in the serum was significantly decreased (P less then 0.01). Therefore, the application of Gn overexpression vector can ameliorate the intestinal inflammatory injury and repair the mucosal barrier in colitis mice, which further suggests the clinical therapeutic potential of GC-C agonists in IBD. Obstructive sl