https://ml133inhibitor.com/the....rmally-caused-actini
While pharmacological Drp1 inhibition is put ahead as neuroprotective, the specificity and apparatus regarding the inhibitor utilized is controversial. Right here, we provide genetic evidence that Drp1 inhibition is neuroprotective. Drp1 is triggered by dephosphorylation of an inhibitory phosphorylation website, Ser637. We identify Bβ2, a mitochondria-localized protein phosphatase 2A (PP2A) regulatory subunit, as a neuron-specific Drp1 activator in vivo Bβ2 KO mice of both sexes display elongated
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