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PURPOSE To analyze the clinical characteristics, management choices, and outcomes of cases of methicillin-resistant Staphylococcal aureus (MRSA) keratitis. DESIGN Retrospective interventional case series METHODS 52 culture-proven (52 eyes) cases of MRSA keratitis diagnosed and treated at the University of Pittsburgh Medical Center were identified and reviewed. RESULTS Mean age was 66.6±19.2 years with median follow-up time of 147 days. The most prevalent risk factors included a history of ocular surgery (62.5%), topical corticosteroid us