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To investigate whether tracheostomy placement in infants requiring high ventilator pressure is safe and effective. Case series with chart review. Tertiary children's hospital. Fifty ventilator-dependent neonatal intensive care unit patients who underwent tracheotomy from 2009 to 2018 were included. Patients requiring high ventilator pressures were compared to those requiring low ventilator pressures. Demographics, comorbidities, and surgical and clinical data were recorded. Thirty-two percent (n = 16) had low ventilator settings at the
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