https://www.selleckchem.com/pr....oducts/Belinostat.ht
02 mg/kg, i.p.) and mimicked by a selective COMT inhibitor, OR-486 (10 mg/kg, i.p.). Hispidulin increased extracellular dopamine levels in the PFC of chronic PCP-treated mice. In isolated mutDISC1 mice, hispidulin also rescued social withdrawal. In both models, intra-PFC microinjection of a D1 R agonist (SKF81297 10 nmol/mouse/bilateral) reversed the impairment of Ser897 phosphorylation at the NR1 subunit of NMDA receptors, suggesting the association between NR1 Ser897 -phosphorylation and D1 R activation in the PFC exits in both mod