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Metronomic therapy is a good option for locally advanced oral cancers in COVID-19 pandemic time.•In the present situation there is a need for a therapy that ensure patients remain operable while awaiting surgery.•Metronomic therapy is easily deliverable, minimally toxic, home based and cost effective.Objectives Squamous cell carcinoma (SCC) of the tongue is one of the most common oral cancers, tongue dorsum being a site of low incidence of primary SCC. We report a rare case of SCC of the tongue dorsum in a 69-year-old man having a histo