https://ml141inhibitor.com/ter....m-pattern-with-the-v
The natural products combretastatin A-1 (CA1) and combretastatin A-4 (CA4) function as potent inhibitors of tubulin polymerization so when selective vascular disrupting agents (VDAs) in tumors. Bioreductively activatable prodrug conjugates (BAPCs) can boost selectivity by providing as substrates for reductase enzymes particularly in hypoxic areas of tumors. A series of CA1-BAPCs incorporating nor-methyl, mono-methyl, and gem-dimethyl nitrothiophene triggers had been synthesized together with corresponding
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