https://www.selleckchem.com/pr....oducts/empagliflozin
The anti-inflammatory effects of amlexanox could be abolished by the application of cAMP antagonist or PDE4B siRNA. In addition to PDE4B, the activities of PDE1C, 3A, and 3B were directly inhibited by amlexanox. Our results provide mechanistic insight into the clinical utility of amlexanox for the treatment of inflammatory disorders and might contribute to extending the clinical indications of amlexanox.Purpose Present-day treatment planning in carbon ion therapy is conducted with assumptions for a limited number of tissue