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Among 3,000 prospectively enrolled patients, 1,239 (41.3%) demonstrated a negative HOME-CoV rule finding. The false-negative rate of the HOME-CoV rule was 4 in 1,239 (0.32%; 95%CI, 0.13%-0.84%), and its area under the receiver operating characteristic curve was 80.9 (95%CI, 76.5-85.2). On the adjusted populations, 25 of 1,274 patients (1.95%) experienced an adverse evolution during the observational period vs12 of 1,274 patients (0.95%) during the interventional period -1.00 (95%CI, -1.86 to -0.15). During the observational period, 858 pati