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Whilenutritional management of body composition and LGCI have been studied, the nutrients (and theirquantities) most affected by stressors and those which may act toward the alleviation of stressfulstate, ultimately leading to better body composition outcomes, need to be elucidated.This study examines the statistical implications, and their possible implementation, of the "Draft guideline on quality and equivalence of topical products" issued by the European Medicines Agency in 2018, with particular focus on the section devoted to quali