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© 2020 S. Karger AG, Basel.The relationship between the elastic property of solid materials and friction has been discussed and studied by theoretical calculation and analysis. In the present work, we perform an experimental study concerning this relationship. AFM scanning of four different transition metal dichalcogenides (TMDCs) is conducted under different experimental conditions. It is found that materials with smaller vertical interlayer force constant, which also means smaller elasticity modulus, have larger frictio