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Previous studies have reported inconsistent associations between reproductive factors and lung cancer. We used data from the Japan Public Health Center-based Prospective Study, which included 400 incident lung cancer cases (305 adenocarcinoma) among 42,615 never-smoking women followed for a median of 21 years, to examine the associations of reproductive and hormonal factors with lung cancer by histological type using Cox proportional hazards models. Longer fertility span (≥36 years vs. ≤32 years) was associated with increased risk of lung
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