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38, 0.55; Ptrend less then 0.001) for vitamin B2, 0.55 (95%CI 0.46, 0.76; Ptrend less then 0.001) for vitamin B6 and 0.72 (95%CI 0.60, 0.86; Ptrend less then 0.001) for vitamin B12, respectively. No statistically significant association was found between methionine intake and colorectal cancer risk. Stratified analysis by sex showed that the inverse associations between vitamin B12 and methionine intake and colorectal cancer risk were found only among women. This study indicated that higher intake of folate, vitamin B2, vitamin B6 and v