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How a VC Can Affect Your Heart A lot of people experience occasional PVCs without any problems. But if they occur frequently, PVCs can weaken your heart muscle and increase your risk of heart failure. The rhythm of your heart is controlled by a bundle of nerve fibers situated in the upper right corner of your heart. This is known as the sinoatrial node, or SA. Electrical signals are transmitted from there to the lower heart chambers, or ventricles. Causes PVCs occur when the electrical impulse which normally starts your he